北大構造生物学研究室

オートファジーの構造生物学

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Home > メンバー > 野田　展生

		野田　展生
		北海道大学大学院構造生物学研究室助教
		nn@pharm.hokudai.ac.jp
		薬学博士

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Kumeta H, Watanabe M, Nakatogawa H, Yamaguchi M, Ogura K, Adachi W, Fujioka Y, Noda NN, Ohsumi Y, Inagaki F.
The NMR structure of the autophagy-related protein Atg8.
J Biomol NMR., 47, 237-241 (2010)

Noda NN, Ohsumi Y, Inagaki F.
Atg8-family interacting motif crucial for selective autophagy.
FEBS Lett., 584, 1379-1385 (2010)

Watanabe Y, Noda NN, Kumeta H, Suzuki K, Ohsumi Y, Inagaki F.
Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by ATG19 and ATG34.
J Biol Chem (2010)

Yamaguchi M, Noda NN, Nakatogawa H, Kumeta H, Ohsumi Y, Inagaki F.
Autophagy-related protein (Atg) 8-family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway.
J Biol Chem (2010)

Fujioka Y, Noda NN, Nakatogawa H, Ohsumi Y, Inagaki F.
The dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy.
J Biol Chem, 285, 1508-1515 (2010)

Kabeya Y, Noda NN, Fujioka Y, Suzuki K, Inagaki F, Ohsumi Y.
Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
Biochem Biophys Res Commun., 389, 612-615 (2009)

Watanabe Y, Noda NN, Honbou K, Suzuki K, Sakai Y, Ohsumi Y, Inagaki F
Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway
Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 571-3 (2009)

Satoo K, Noda NN, Kumeta H, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
The structure of Atg4B-LC3 complex reveals the mechanism of LC3-processing and delipidation during autophagy
EMBO J, 28, 1341-1350 (2009)

Noda, N.N., Ohsumi, Y., Inagaki, F.
Atg systems from the protein structural point of view,
Chem. Rev., 109, 1587-1598 (2009)

Noda NN, Kumeta H, Nakatogawa H, Satoo K, Adachi W, Ishii J, Fujioka Y, Ohsumi Y, Inagaki F.
Structural basis of target recognition by Atg8/LC3 during selective autophagy.
Genes Cells, 13, 1211-1218 (2008)

Fujioka Y, Noda NN, Matsushita M, Ohsumi Y, Inagaki F.
Crystallization of the coiled-coil domain of Atg16 essential for autophagy
Acta Crystallogr Sect F Struct Biol Cryst Commun., 64, 1046-1048 (2008)

Fujioka Y, Noda NN, Fujii K, Yoshimoto K, Ohsumi Y, Inagaki F.
In vitro reconstitution of plant ATG8 and ATG12conjugation systems essential for autophagy
J Biol Chem., 283, 1921-1928 (2008)

Noda NN, Fujioka Y, Ohsumi Y, Inagaki F.
Crystallization of the Atg12-Atg5 conjugate bound to Atg16 by the free interface diffusion method.
J Synchrotron Radiat., 15, 266-268 (2008)

Nishida K, Horiuchi M, Noda NN, Takahasi K, Iwasaki N, Minami A, Inagaki F.
Crystallization and preliminary crystallographic analysis of the Tob-hCaf1 complex
Acta Crystallograph Sect F Struct Biol Cryst Commun., 63, 1061-1063 (2007)

Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y.
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.
J Biol Chem., 282, 37298-37302 (2007)

Matsushita M, Suzuki NN, Obara K, Fujioka Y, Ohsumi Y, Inagaki F.
Structure of Atg5.Atg16, a complex essential for autophagy.
J Biol Chem., 282, 6763-6772 (2007)

Yamada Y, Suzuki NN, Hanada T, Ichimura Y, Kumeta H, Fujioka Y, Ohsumi Y, Inagaki F.
The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation.
J Biol Chem., 282, 8036-8043 (2007)

Satoo K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
Crystallization and preliminary crystallographic analysis of human Atg4B-LC3 complex.
Acta Crystallogr Sect F Struct Biol Cryst Commun., 63, 99-102 (2007)

Honbou K, Minakami R, Yuzawa S, Takeya R, Suzuki NN, Kamakura S, Sumimoto H, Inagaki F.
Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding.
EMBO J., 26, 1176-1186 (2007)

Adachi W, Suzuki NN, Fujioka Y, Suzuki K, Ohsumi Y, Inagaki F.
Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway.
Acta Crystallogr Sect F Struct Biol Cryst Commun., 63, 200-203 (2007)

Yamaguti M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F.
Crystallization and preliminary X-ray analysis of Atg10.
Acta Crystallogr Sect F Struct Biol Cryst Commun., 63, 443-445 (2007)

Yamada Y, Suzuki NN, Fujioka Y, Ichimura Y, Ohsumi Y, Inagaki F.
Crystallization and preliminary X-ray analysis of Atg3.
Acta Crystallogr Sect F Struct Biol Cryst Commun., 62, 1016-1017 (2006)

Honbou K, Yuzawa S, Suzuki NN, Fujioka Y, Sumimoto H, Inagaki F.
Crystallization and preliminary crystallographic analysis of p40phox, a regulatory subunit of NADPH oxidase.
Acta Crystallogr Sect F Struct Biol Cryst Commun., 62, 1018-1020 (2006)

Matsushita M, Suzuki NN, Fujioka Y, Ohsumi Y, Inagaki F.
Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagy.
Acta Crystallogr Sect F Struct Biol Cryst Commun., 62, 1021-1023 (2006)

Hirano Y, Yoshinaga S, Takeya R, Suzuki NN, Horiuchi M, Kohjima M, Sumimoto H, Inagaki F.
Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.
J Biol Chem., 280, 9653-9661 (2005)

Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y.
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
Mol Cell Biol., 25, 7239-7248 (2005)

Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.
J Biol Chem., 280, 40058-40065 (2005)

Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F.
The crystal structure of plant ATG12 and its biological implication in autophagy.
Autophagy, 1, 119-126 (2005)

Hashida S, Yuzawa S, Suzuki NN, Fujioka Y, Takikawa T, Sumimoto H, Inagaki F, Fujii H.
Binding of FAD to cytochrome b558 is facilitated during activation of the phagocyte NADPH oxidase, leading to superoxide production.
J Biol Chem., 279, 26378-26386 (2004)

Yuzawa S, Ogura K, Horiuchi M, Suzuki NN, Fujioka Y, Kataoka M, Sumimoto H, Inagaki F.
Solution structure of the tandem Src homology 3 domains of p47phox in an autoinhibited form.
J Biol Chem., 279, 29752-29760 (2004)

Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F.
Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase.
Structure, 12, 751-764 (2004)

Yuzawa S, Suzuki NN, Fujioka Y, Ogura K, Sumimoto H, Inagaki F.
A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase.
Genes Cells, 9, 443-456 (2004)

Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8.
Genes Cells, 9, 611-618 (2004)

Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.
Crystallization and preliminary X-ray analysis of LC3-I.
Acta Crystallogr D Biol Crystallogr., 59, 1464-1465 (2003)

Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F.
The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.
J Biol Chem., 278, 31380-31384 (2003)

Suzuki NN, Koizumi K, Fukushima M, Matsuda A, Inagaki F.
Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2.
Acta Crystallogr D Biol Crystallogr., 59, 1477-1478 (2003)

Yuzawa S, Suzuki NN, Fujioka Y, Ogura K, Sumimoto H, Inagaki F.
Crystallization and preliminary crystallographic analysis of the autoinhibited form of the tandem SH3 domain of p47(phox).
Acta Crystallogr D Biol Crystallogr., 59, 1479-1480 (2003)

Honbou K, Suzuki NN, Horiuchi M, Taira T, Niki T, Ariga H, Inagaki F.
Crystallization and preliminary crystallographic analysis of DJ-1, a protein associated with male fertility and parkinsonism.
Acta Crystallogr D Biol Crystallogr., 59, 1502-1503 (2003)

Takahasi K, Suzuki NN, Horiuchi M, Mori M, Suhara W, Okabe Y, Fukuhara Y, Terasawa H, Akira S, Fujita T, Inagaki F.
X-ray crystal structure of IRF-3 and its functional implications.
Nat Struct Biol., 10, 922-927 (2003)

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